DMTr-2′O-TBDMS-rA(bz) Phosphoramidite belongs to the group of 2′O-TBDMS RNA Phosphoramidites.
Application
RNA interference (RNAi) has become a popular tool for the sequence-specific inhibition of gene expression and can be used in target validation and other drug development techniques. The most convenient method to provide sequence-specific RNA oligonucleotides is a chemical synthesis on a solid support with RNA phosphoramidites and RNA CPG, analogous to DNA synthesis.
Features and Benefits
Industry standard 2′O-TBDMS protective group
Consistent lot-to-lot purity and performance
Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as activator; best results are obtained with Activator 42
Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap A
Manufactured under a certified ISO 9001 quality system
Other Notes
The unique properties of RNA have stimulated the development of a variety of applications in diagnostics and therapeutics, as well as in basic molecular biology research where RNA can be used as:
Catalytic agents (ribozymes)
Affinity ligands (aptamers)
Agents to induce gene silencing (RNA interference)
