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Home ProductsPhosphoramiditesDMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite

DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite

DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite
Basic Information
Place of Origin: CHINA
Brand Name: Allbiosyn
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CAS No.: 144089-97-4 Molecular Formula: C44H53FN7O8P
Molecular Weight: 857.90 Appearance: White Powder
Purity: HPLC ≥99.0% Storage: -20℃

A phosphoramidite (RO)2PNR2 is a monoamide of a phosphite diester. The key feature of phosphoramidites is their markedly high reactivity towards nucleophiles catalyzed by weak acids e.c., triethylammonium chloride or 1H-tetrazole. In these reactions, the incoming nucleophile replaces the NR2 moiety.

 

2'-Deoxy-5'-O-DMTr-2'-fluoro-N2-isobutyrylguanosine 3'-CE phosphoramidite is a novel nucleoside analog, which has potent antiviral activity against HIV and other retroviruses. It is synthesized from 5'-O-DMTr-2'-fluoro-N2-isobutyrylguanosine by the reaction of sodium bicarbonate with 2',3'-dideoxyadenosine in the presence of an activator. The product can be used for the synthesis of RNA or DNA for use as probes, primers, and templates in polymerase chain reactions (PCRs).

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