| Place of Origin: | CHINA |
|---|---|
| Brand Name: | Allbiosyn |
| CAS No.: | 251647-55-9 | Molecular Formula: | C47H60N7O10P |
|---|---|---|---|
| Molecular Weight: | 914.01 | Appearance: | White Powder |
| Purity: | HPLC ≥99.0% | Storage: | -20℃ |
| Highlight: | DMTr-2'-O-MOE-rG(iBu)-3'-CE -Phosphoramidite,251647-55-9 DMTr-2'-O-MOE-rG(iBu)-3'-CE -Phosphoramidite |
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A phosphoramidite (RO)2PNR2 is a monoamide of a phosphite diester. The key feature of phosphoramidites is their markedly high reactivity towards nucleophiles catalyzed by weak acids e.c., triethylammonium chloride or 1H-tetrazole. In these reactions, the incoming nucleophile replaces the NR2 moiety.
Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMTr-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMTr-2'-O-MOE-G(iBu)-CEP, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.
