3'-O-TBDMS-2'-dC(Ac)

White, off-white to light yellow powder, free from visible foreign matter, 

UPLC≥98.0%

Product Name: 3'-O-TBDMS-2'-dC(Ac)

Product Description:

3'-O-TBDMS-2'-dC(Ac) is a modified nucleoside designed for nucleic acid research, therapeutic development, and related applications. It possesses unique structural features and enhanced properties that offer various advantages in terms of stability, functionality, and applications. The following features, parameters, functions, and applications highlight the key aspects of this product:

1. Chemical Structure: 3'-O-TBDMS-2'-dC(Ac) is a modified deoxycytidine nucleoside with a tert-butyldimethylsilyl (TBDMS) group protecting the 3'-hydroxyl group and an acetyl (Ac) group at the 2'-position. This modification introduces specific properties while retaining the natural structure of deoxycytidine.

2. Molecular Formula: C18H27N3O7Si

3. Molecular Weight: 429.51 g/mol

4. Physical Properties: Off-white to pale yellow powder

5. Solubility: Soluble in common organic solvents

Key Features:

1. Protection of 3'-Hydroxyl Group: The TBDMS group in 3'-O-TBDMS-2'-dC(Ac) protects the 3'-hydroxyl group, allowing for controlled deprotection during oligonucleotide synthesis.

2. Acetyl Group at 2'-Position: The acetyl group at the 2'-position can introduce additional functionality and properties, enabling diverse applications.

3. Enhanced Stability: The modifications in 3'-O-TBDMS-2'-dC(Ac) enhance its stability, making it suitable for various applications requiring resistance to enzymatic degradation.

Functions:

1. Nucleic Acid Research: 3'-O-TBDMS-2'-dC(Ac) serves as a valuable tool in nucleic acid research, including DNA synthesis, DNA sequencing, and investigations of DNA-protein interactions.

2. Chemical Synthesis: It can be used as a building block in chemical synthesis for the preparation of modified nucleic acids, oligonucleotides, or other nucleic acid-based materials.

Applications:

1. Therapeutic Development: The unique structural features of 3'-O-TBDMS-2'-dC(Ac) make it a promising candidate for therapeutic development, particularly in the field of nucleic acid-based therapies and gene regulation.

2. Diagnostic Assays: This modified nucleoside can be used in the development of diagnostic assays, such as PCR-based assays, to improve specificity and sensitivity.

Table: Properties of 3'-O-TBDMS-2'-dC(Ac)

In summary, 3'-O-TBDMS-2'-dC(Ac) is a modified nucleoside designed for nucleic acid research, therapeutic development, and chemical synthesis applications. It offers protection of the 3'-hydroxyl group and introduces an acetyl group at the 2'-position, providing enhanced stability and additional functionality. This modified nucleoside serves as a valuable tool in nucleic acid research and can be used in therapeutic development and diagnostic assays. Its unique structural features make it suitable for diverse applications in the field of nucleic acid-based therapies and gene regulation.