5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

White,off-white to faint yellow powder, 2-8℃ (for long-term), 

HPLC ≥98%

Product Name: 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Product Description:

5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur is a modified nucleoside designed for use in nucleic acid research, therapeutic development, and related applications. It possesses unique structural features and enhanced properties that offer various advantages in terms of stability, functionality, and applications. The following features, parameters, and functions highlight the key aspects of this product:

1. Chemical Structure: 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur is a modified uridine nucleoside with an amino group at the 5'-position, a TBDMS (tert-butyldimethylsilyl) group at the 3'-position, and a 4'-C-locked modification. It contains a 2'-O modification, providing increased stability and unique functionalities.

2. Molecular Formula: C17H29N3O6Si

3. Molecular Weight: 395.51 g/mol

4. Physical Properties: Off-white to pale yellow powder

5. Solubility: Soluble in common organic solvents (e.g., DMSO, methanol)

Key Features and Functions:

1. Enhanced Stability: The 4'-C-locked modification and TBDMS group at the 3'-position confer increased stability to 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur, making it suitable for various applications requiring resistance to enzymatic degradation.

2. Functional Group Introduction: The amino group at the 5'-position provides a versatile functionality for further modifications, conjugations, or labeling.

3. Nucleic Acid Research: 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur serves as a valuable tool in nucleic acid research, including RNA synthesis, RNA structure determination, and investigations of RNA-protein interactions.

4. Therapeutic Development: The unique structural features of 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur make it a promising candidate for therapeutic development, particularly in the field of antisense oligonucleotides or RNA-based therapeutics.

5. Chemical Synthesis: It can be used as a building block in chemical synthesis for the preparation of modified nucleic acids, nucleic acid probes, or other nucleic acid-based materials.

Table: Properties of 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

In summary, 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur is a modified nucleoside designed for nucleic acid research, therapeutic development, and chemical synthesis applications. It offers enhanced stability, functional group introduction, and versatile functionalities for various research and therapeutic purposes. Its unique structural features make it a valuable tool in nucleic acid studies and hold promise for the development of RNA-based therapeutics.