Peracetylated GalNAc PEG linker-Azide

Colorless to pale yellow oil, free from visible foreign matter, UPLC≥98%

Product Name: Peracetylated GalNAc PEG linker-Azide

Product Description:

Peracetylated GalNAc PEG linker-Azide is a specialized compound used in the field of chemical biology and drug development. It is designed as a versatile tool for the conjugation of biomolecules, particularly targeting the modification of proteins and peptides with GalNAc residues. The peracetylated GalNAc PEG linker-Azide provides a stable and bioorthogonal platform for site-specific labeling, glycan engineering, and targeted delivery applications.

Key Features:

1. Peracetylated GalNAc Modification: The compound consists of a peracetylated GalNAc moiety, which enables selective and efficient modification of biomolecules containing hydroxyl or amino groups. This modification is essential for achieving precise and controlled glycan engineering.

2. PEG Linker: The GalNAc PEG linker portion of the compound incorporates a polyethylene glycol (PEG) spacer, facilitating improved solubility, flexibility, and accessibility for the modified biomolecules. The PEG linker enhances the stability and bioactivity of the conjugated target molecules.

3. Azide Functionality: The presence of an azide group in the compound offers a bioorthogonal handle for subsequent click chemistry reactions. This allows for the conjugation of various functional molecules, such as fluorophores, biotin, or drug payloads, to the modified biomolecules.

4. Stability and Compatibility: Peracetylated GalNAc PEG linker-Azide is stable under typical storage conditions and compatible with a wide range of reaction conditions. This ensures its reliability and applicability in diverse experimental setups.

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Parameters:

Functions:

1. Site-Specific Labeling: The presence of the GalNAc moiety allows for site-specific modification of biomolecules, enabling precise attachment of desired functional groups or tags.

2. Glycan Engineering: Peracetylated GalNAc PEG linker-Azide facilitates the introduction of GalNAc residues onto proteins and peptides, mimicking natural glycosylation patterns. This enables the study of glycan-mediated processes and their impact on biological function.

3. Targeted Delivery: The compound can be utilized for targeted delivery of therapeutic agents or imaging probes by conjugating them to GalNAc-modified biomolecules. This approach enables selective recognition and uptake by specific cellular receptors overexpressed in certain diseases.

4. Click Chemistry Reactions: The azide functionality of the compound allows for efficient and specific conjugation through click chemistry reactions, providing a wide range of possibilities for subsequent functionalization or bioconjugation.

5. Note: Peracetylated GalNAc PEG linker-Azide is a versatile compound designed for biomolecule modification, glycan engineering, and targeted delivery applications. The table presents its key features, parameters, and functions, highlighting its role in site-specific labeling, glycan engineering, targeted delivery, and compatibility with click chemistry reactions.