Name: m7G(5')ppp(5')(2'-OMeA)pG·NH4
Brand: m7G(5')ppp(5')(2'-OMeA)pG·NH4
SKU: m7G(5')ppp(5')(2'-OMeA)pG·NH4
Rating: 4.8 (120 reviews)

Clear to slightly yellow solution,-20℃ or below,HPLC ≥99%

Product Name: m7G(5')ppp(5')(2'-OMeA)pG·NH4

Product Description:

m7G(5')ppp(5')(2'-OMeA)pG·NH4 is a modified RNA cap analog commonly used in molecular biology research and RNA-related studies. It is a complex structure consisting of a methylated guanosine cap (m7G) linked to a dinucleotide bridge [(5')ppp(5')] and a 2'-O-methyladenosine (2'-OMeA) residue. The ammonium ion (NH4) is included to enhance stability and solubility. This cap analog mimics the structure found at the 5' end of eukaryotic mRNA, providing a valuable tool for studying mRNA capping and translation processes.

Key Features:

Modified RNA Cap: m7G(5')ppp(5')(2'-OMeA)pG·NH4 contains a methylated guanosine cap (m7G) that closely resembles the natural cap structure found on eukaryotic mRNA. This modification enables the study of cap-dependent translation initiation and mRNA stability.
Dinucleotide Bridge: The dinucleotide bridge [(5')ppp(5')] connects the cap structure to the 2'-O-methyladenosine (2'-OMeA) residue, providing stability and maintaining the integrity of the cap analog during experimental procedures.
2'-O-Methylation: The 2'-O-methyladenosine (2'-OMeA) modification enhances the stability and resistance of the cap analog to nuclease degradation, ensuring reliable results in downstream applications.
Ammonium Ion (NH4): The inclusion of the ammonium ion enhances the solubility and stability of the cap analog, facilitating its use in various experimental setups.

Applications:

Application	Description
mRNA Capping Studies	m7G(5')ppp(5')(2'-OMeA)pG·NH4 is widely used as a substrate in in vitro transcription reactions to study mRNA capping and related processes. It allows researchers to investigate the effects of cap modifications on translation initiation, mRNA stability, and other downstream events.
Translation Initiation Studies	The cap analog is utilized to examine cap-dependent translation initiation mechanisms in eukaryotic cells. It enables researchers to study the role of the cap structure in ribosome recognition, translation efficiency, and protein synthesis.
RNA Structure and Function Studies	The cap analog serves as a tool for investigating the structure and function of RNA molecules. It can be incorporated into RNA transcripts or used as a probe to study RNA-protein interactions, RNA folding, and RNA localization.
mRNA Stability Analysis	Researchers employ the cap analog to investigate the impact of cap modifications on mRNA stability and decay pathways. It enables the study of mRNA turnover mechanisms and contributes to understanding post-transcriptional gene regulation.

Tag:

Place of Origin:	China

Price:	Negotiable
Packaging Details:	10ml，100ml, 500ml
Delivery Time:	7-15 workdays
Payment Terms:	LC, T/T, PayPal, Western Union, Small-amount payment, Money Gram
Supply Ability:	1000L/month

	Allbiosyn Biotechnology Co., Ltd
	Building 1,883-885 Pinggang Road, Lingang District,Free Trade Zone, Shanghai, China.
	86-18666985712
	info@allbiosyn.com

m7G(5')ppp(5')(2'-OMeA)pG·NH4

Clear Cap analog