3'-NH2-ddT, 3'-amino-2', 3'-dideoxythymidine

Off-white to yellow powder,2-8℃, Keep in a dark and dry place ,HPLC ≥99%

Product Name: 3'-Amino-2',3'-dideoxythymidine

Product Performance and Characteristics:

1. Chemical Structure: 3'-Amino-2',3'-dideoxythymidine is a modified thymidine nucleoside with an amino group at the 3'-position and lacking both the 2'- and 3'-hydroxyl groups.
2. Molecular Formula: C10H15N3O3
3. Molecular Weight: 225.24 g/mol
4. Physical Appearance: White to off-white crystalline powder
5. Solubility: Soluble in water and organic solvents like DMSO and methanol

Applications:

1. Antiviral Activity: 3'-Amino-2',3'-dideoxythymidine, also known as zidovudine or AZT, is a potent antiviral drug used in the treatment of HIV/AIDS. It inhibits the reverse transcriptase enzyme and prevents viral replication.
2. Research Tool: It is utilized in laboratory research to study the mechanisms of viral replication and drug resistance in HIV.
3. Nucleoside Analog: 3'-Amino-2',3'-dideoxythymidine is a nucleoside analog that can be incorporated into growing DNA chains, leading to premature termination of DNA synthesis.
4. Chemotherapeutic Agent: It is being investigated as a potential chemotherapeutic agent for the treatment of certain types of cancer.
5. Radiolabeling: 3'-Amino-2',3'-dideoxythymidine can be radiolabeled with isotopes like tritium or carbon-14 for tracing and quantification purposes in biochemical studies.
6. Diagnostic Applications: It is used in diagnostic assays, such as PCR (polymerase chain reaction), for the amplification and detection of DNA sequences.

Table: Properties of 3'-Amino-2',3'-dideoxythymidine

In summary, 3'-Amino-2',3'-dideoxythymidine is a modified thymidine nucleoside with antiviral properties, primarily used in the treatment of HIV/AIDS. It also finds applications in laboratory research, nucleoside analog studies, potential cancer therapy, radiolabeling, and diagnostic assays. The table provides a concise overview of the product's properties and applications.