N2-iBu-3',5'-TIPDS-15N1-Gr N2-iBu-3',5'-O-TIPDS-15N1-guanosine

Product Name: N2-iBu-3',5'-TIPDS-15N1-Gr

Product Description:

N2-iBu-3',5'-TIPDS-15N1-Gr is a novel modified nucleoside designed for use in nucleic acid research and related applications. It is characterized by its unique structure and enhanced properties, offering various advantages in terms of stability, functionality, and applications. The following features and parameters highlight the key aspects of this product:

1. Chemical Structure: N2-iBu-3',5'-TIPDS-15N1-Gr is a modified nucleoside consisting of a guanine base attached to a ribose sugar via a 3',5'-TIPDS (triisopropylsilyl) linker at the N2 position. It contains a 15N isotope substitution, providing isotopic labeling capabilities.

2. Molecular Formula: C15H22N7O4Si

3. Molecular Weight: 394.47 g/mol

4. Physical Properties: Off-white to pale yellow powder

5. Solubility: Soluble in common organic solvents (e.g., DMSO, methanol)

Key Features and Functions:

1. Enhanced Stability: The incorporation of the 3',5'-TIPDS linker enhances the stability of N2-iBu-3',5'-TIPDS-15N1-Gr, making it suitable for various applications requiring resistance to enzymatic degradation.

2. Isotopic Labeling: The presence of a 15N isotope substitution enables isotopic labeling, facilitating studies involving nucleic acid dynamics, interactions, and tracking.

3. Nucleic Acid Research: N2-iBu-3',5'-TIPDS-15N1-Gr serves as a valuable tool in nucleic acid research, including DNA and RNA synthesis, structural studies, and investigations of nucleic acid-protein interactions.

4. NMR Spectroscopy: The isotopic labeling allows for accurate and detailed NMR spectroscopic analysis, providing insights into structural and conformational dynamics of nucleic acids.

5. Biophysical Studies: The modified structure of N2-iBu-3',5'-TIPDS-15N1-Gr offers new possibilities for biophysical studies, such as probing nucleic acid folding, stability, and recognition mechanisms.

Table: Properties of N2-iBu-3',5'-TIPDS-15N1-Gr

In summary, N2-iBu-3',5'-TIPDS-15N1-Gr is a modified nucleoside designed for nucleic acid research, offering enhanced stability, isotopic labeling capabilities, and various applications in the fields of structural biology, biophysics, and NMR spectroscopy. Its unique structure and properties make it a valuable tool for investigating nucleic acid dynamics, interactions, and structural characterization.